MarketplacePad Disease What is the difference between restless legs syndrome and PAD - peripheral arterial disease? Thank you in advance. peripheral arterial disease (PAD) and Restless Legs Syndrome (RLS) can have symptoms in common, but are very different diseases. They have, however, both primarily affect the legs, and both can be treated. However, the causes of PAD are easier to identify the causes of RLS in many cases. Posted on January 10, 2010.
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